{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:06:54Z","timestamp":1792858014942,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PWZxk2022\u201001"],"award-info":[{"award-number":["PWZxk2022\u201001"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011488","name":"Health and Family Planning Committee of Pudong New Area","doi-asserted-by":"publisher","award":["PKJ2023\u2010Y04"],"award-info":[{"award-number":["PKJ2023\u2010Y04"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011488","name":"Health and Family Planning Committee of Pudong New Area","doi-asserted-by":"publisher","award":["PWRq2023\u201019"],"award-info":[{"award-number":["PWRq2023\u201019"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute myocardial infarction (AMI)\u00a0is associated with well\u2010established metabolic risk factors, especially hyperlipidemia and obesity. Myocardial ischemia\u2010reperfusion injury (mIRI) significantly offsets the therapeutic efficacy of revascularization. Previous studies indicated that disrupted lipid homeostasis can lead to lipid peroxidation damage and inflammation, yet the underlying mechanisms remain unclear. Here, the study demonstrates that hyperlipidemia is a key driver of mIRI. Long\u2010chain fatty acyl\u2010CoA synthetase 1 (ACSL1) is upregulated in both hyperlipidemia and AMI patients. ACSL1 expression is induced by a high\u2010fat microenvironment (oxLDL and palmitic acid) in a concentration\u2010dependent manner. Interestingly, the protein level is positively correlated with total cholesterol level and thromboinflammatory biomarkers. Furthermore, ACSL1 reprogrammed lipid metabolism in monocytes, leading to the accumulation of lysophosphatidylcholine (LPC)\/lysophosphatidic acid (LPA). The monocytic LPC\/LPA axis accelerated lipid peroxidation and neutrophil extracellular traps (NETs)\u2010induced thromboinflammation via the paracrine effect. The main LPA producer Autotaxinis is also induced under high\u2010fat conditions and then exerts thromboinflammation response through converted LPC to LPA. Finally, ACSL1 knockdown or NETs release inhibitor (DNase I or GSK484) significantly alleviated mIRI in mice. These findings highlight ACSL1 and NETosis as potential key targets for preventing mIRI and underscore the lipid peroxidation in the mechanisms of ACSL1\u2010mediated thromboinflammation.<\/jats:p>","DOI":"10.1002\/advs.202406359","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T13:24:44Z","timestamp":1737638684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["ACSL1 Aggravates Thromboinflammation by LPC\/LPA Metabolic Axis in Hyperlipidemia Associated Myocardial Ischemia\u2010Reperfusion Injury"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-5557","authenticated-orcid":false,"given":"Shuai","family":"Jiang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueguang","family":"Lin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine J.S.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences and Human Phenome Institute Fudan University  Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Affiliated Hospital of Nantong University  Nantong 226006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Tong","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"},{"name":"Department of Vascular Surgery Huashan Hospital Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4849-9973","authenticated-orcid":false,"given":"Jingdong","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Vascular Lesions and Remodeling Department of Vascular Surgery Shanghai Pudong Hospital Fudan University Pudong Medical Center  Shanghai 201399 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613694"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01260"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.09.062"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-022-01027-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.12.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00032-5"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602000000200010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321750"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09160-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117334"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41057"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1212"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.023"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/load036"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22471-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086956"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.119.002806"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00301.2011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001388"},{"key":"e_1_2_9_18_1","volume":"28","author":"Zhang Z.","year":"2022","journal-title":"Med. Sci. Moni."},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-022-00069-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.05.012"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.42248"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318225"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606253113"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163451"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092406"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147683"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220509"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvu077"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.01.002"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200306"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01706-5"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.712539"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2019.06.002"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.07.001"},{"key":"e_1_2_9_28_3","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01312-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102906"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac113"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306388"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202406359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:46:33Z","timestamp":1765827993000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202406359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/advs.202406359"],"URL":"https:\/\/doi.org\/10.1002\/advs.202406359","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"2024-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2406359"}}