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However, laboratory\u2010based nucleic acid amplification tests (NAATs) require costly equipment, designated lab space, and skilled personnel. Additionally, cervical swabs collected by healthcare professionals can be inconvenient, uncomfortable, and reduce privacy, limiting broader application and patient compliance. A SlipChip\u2010based Integrated Point\u2010of\u2010Care (SIPOC) system featuring an injection\u2010molded SlipChip is presented with preloaded reagents for nucleic acid extraction and a portable four\u2010channel real\u2010time quantitative PCR instrument for detection. This system incorporates a self\u2010sampling method that allows participants to collect their own vaginal swabs, with the \u03b2\u2010Globin gene as a control. After testing 130 participants for HPV\u201016 and HPV\u201018, 97.7% of the self\u2010collected samples are valid. Among valid samples, 25 tested positive for HPV\u201016 and 9 for HPV\u201018. Compared to Roche's standard HPV PCR test, the SIPOC system shows 100% positive predictive value (PPV) for both HPV\u201016 and HPV\u201018 and negative predictive values (NPVs) of 99.0% and 99.1%, respectively. This system is promising for HPV screening in resource\u2010limited settings and adaptable for other point\u2010of\u2010care NAAT applications, including home testing.<\/jats:p>","DOI":"10.1002\/advs.202406367","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T12:05:33Z","timestamp":1727265933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An Injection Molded SlipChip with Self\u2010Sampling for Integrated Point\u2010of\u2010Care Testing of Human Papilloma Virus"],"prefix":"10.1002","volume":"11","author":[{"given":"Jiajie","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangli","family":"Dong","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyi","family":"Sheng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Lai","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200030 China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-330X","authenticated-orcid":false,"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  1954 Huashan Road Shanghai 200030 China"},{"name":"Hefei Early Cancer Screening Innovation Technology Institute Hefei Inovation Industrial Park  Wangjiang West Road Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2886"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.162"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29409"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10227-w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1973"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00110-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","unstructured":"WHO Vaccine2009 27 7236.","DOI":"10.1016\/j.vaccine.2009.05.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-0577-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1460-0"},{"key":"e_1_2_10_11_1","volume-title":"WHO guideline for screening and treatment of cervical pre\u2010cancer lesions for cervical cancer prevention","year":"2021"},{"key":"e_1_2_10_12_1","first-page":"122a","volume":"96","author":"Yang J.","year":"2016","journal-title":"Lab. 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