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The extracellular accumulation of beta\u2010amyloid (A\u03b2) aggregates in the brain is considered as the major event worsening the AD symptoms, but its underlying reason has remained unclear. Here the piezoelectric characteristics of A\u03b2 aggregates are revealed. The vector piezoresponse force microscopy (PFM) analysis results exhibit that A\u03b2 fibrils have spiraling piezoelectric domains along the length and a lateral piezoelectric constant of 44.1 pC N<jats:sup>\u20101<\/jats:sup>. Also, the continuous sideband Kelvin probe force microscopy (KPFM) images display that the increment of charge\u2010induced surface potential on a single A\u03b2 fibril is allowed to reach above +1700\u00a0mV in response to applied forces. These findings shed light on the peculiar mechano\u2010electrical surface properties of pathological A\u03b2 fibrils that exceed those of normal body components.<\/jats:p>","DOI":"10.1002\/advs.202406678","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:04:52Z","timestamp":1724072692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lateral Piezoelectricity of Alzheimer's A\u03b2 Aggregates"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6257-1229","authenticated-orcid":false,"given":"Jinhyeong","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"},{"name":"Applied Science Research Institute Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-1813","authenticated-orcid":false,"given":"Soyun","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghan","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-1983","authenticated-orcid":false,"given":"Seungbum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-8629","authenticated-orcid":false,"given":"Chan Beum","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  335 Science Road Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1134","volume":"25","author":"Alzheimer A.","year":"1906","journal-title":"Neurol. 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