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Herein, neutrophil\u2010targeting semiconducting polymer nanotheranostics (SSPN\n                    <jats:sub>iNO<\/jats:sub>\n                    ) is reported for second near\u2010infrared (NIR\u2010II) fluorescence imaging\u2010guided trimodal therapy of orthotopic glioblastoma in mouse models. The SSPN\n                    <jats:sub>iNO<\/jats:sub>\n                    are formed based on two semiconducting polymers acting as NIR\u2010II fluorescence probe as well as photothermal conversion agent, respectively. A thermal\u2010responsive nitric oxide (NO) donor and an adenosine 2A receptor (A2AR) inhibitor are co\u2010integrated into SSPN\n                    <jats:sub>iNO<\/jats:sub>\n                    to enable trimodal therapeutic actions. SSPN\n                    <jats:sub>iNO<\/jats:sub>\n                    are surface attached with a neutrophil\u2010targeting ligand to mediate their effective delivery into orthotopic GBM sites via a \u201cTrojan Horse\u201d manner, enabling high\u2010sensitive NIR\u2010II fluorescence imaging. Upon NIR\u2010II light illumination, SSPN\n                    <jats:sub>iNO<\/jats:sub>\n                    effectively generates heat via NIR\u2010II photothermal effect, which not only kills tumor cells and induces immunogenic cell death (ICD), but also triggers controlled NO release to strengthen tumor ICD. Additionally, the encapsulated A2AR inhibitor can modulate immunosuppressive tumor microenvironment by blocking adenosine\u2010A2AR pathway, which further boosts the antitumor immunological effect to observably suppress the orthotopic GBM progression. This study can provide a multifunctional theranostic nanoplatform with cumulative therapeutic actions for NIR\u2010II fluorescence imaging\u2010guided effective GBM treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202406750","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:54:50Z","timestamp":1724075690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neutrophil\u2010Targeting Semiconducting Polymer Nanotheranostics for NIR\u2010II Fluorescence Imaging\u2010Guided Photothermal\u2010NO\u2010Immunotherapy of Orthotopic Glioblastoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Jiansheng","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 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