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However, complete control of the absolute and relative stereochemical configurations of alkyne derivatives remains an unmet synthetic challenge. Herein, a Ni\/Cu dual\u2010catalyzed asymmetric propargylic substitution reaction is presented to produce propargylated products with all\u2010carbon quaternary stereocenters in high yields with significant diastereo\u2010 and enantioselectivities (up to &gt;20:1 dr, &gt;99% ee). The synthesis of all stereochemical variants of methohexital, a widely used sedative\u2010hypnotic drug, exemplifies the efficacy of dual\u2010catalyzed stereodivergent propargylation.<\/jats:p>","DOI":"10.1002\/advs.202406764","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:54:38Z","timestamp":1721879678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ni\/Cu Dual\u2010Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-6612","authenticated-orcid":false,"given":"Xihao","family":"Chang","sequence":"first","affiliation":[{"name":"College of Materials and Chemistry &amp; School of Plant Protection Anhui Agricultural University  Hefei 230036 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