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However, current studies on the pathogenesis of NS are limited. Here, through the integration analysis of proteomics and single\u2010cell transcriptomics, Toll\u2010like\/NF\u2010\u03baB signaling is identified as the key pathway involved in CNS damage caused by\n                    <jats:italic>Tp<\/jats:italic>\n                    . Moreover, monocyte\u2010derived macrophages are key cells involved in the inflammatory response to\n                    <jats:italic>Tp<\/jats:italic>\n                    in the CNS of NS patients. In addition, it is found that inflammatory cells in peripheral blood may cause neurological damage through disruption of the blood\u2012brain barrier (BBB) in individuals with NS. Notably, activation of the Toll\u2010like\/NF\u2010\u03baB signaling pathway, as well as dysregulation of neural function, is likewise validated in an in vitro NS brain organoid model. In conclusion, the results revealed the mechanisms of inflammation\u2010mediated brain injury in\n                    <jats:italic>Tp<\/jats:italic>\n                    \u2010induced NS and provided new ideas for the clinical treatment of\n                    <jats:italic>Tp<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/advs.202406971","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:22:26Z","timestamp":1732245746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Study on the Inflammatory Response of the Brain in Neurosyphilis"],"prefix":"10.1002","volume":"12","author":[{"given":"Qiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Stem cell and Regenerative Medicine Lab Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100730 China"},{"name":"Department of Dermatology Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics  Beijing 102206 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Stem cell and Regenerative Medicine Lab Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100730 China"},{"name":"Department of Dermatology Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing 100730 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Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National 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