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However, the regulation of trophoblast invasion, which is most important during placentation, remains largely unknown. Here, rats, mice, and pigs are used as biomedical models, used scRNA\u2010seq to comparatively elucidate the regulatory mechanism of placental trophoblast invasion, and verified it using a human preeclampsia disease model combined with scStereo\u2010seq. A dual\u2010featured type of immune\u2010featured trophoblast (iTrophoblast) is unexpectedly discovered. Interestingly, iTrophoblast only exists in invasive placentas and regulates trophoblast invasion during placentation. In a normally developing placenta, iTrophoblast gradually transforms from an immature state into a functional mature state as it develops. Whereas in the developmentally abnormal preeclamptic placenta, disordered iTrophoblast transformation leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and ultimately leading to the progression of preeclampsia.<\/jats:p>","DOI":"10.1002\/advs.202407221","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:05:30Z","timestamp":1725519930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cross\u2010Species Insights into Trophoblast Invasion During Placentation Governed by Immune\u2010Featured Trophoblast Cells"],"prefix":"10.1002","volume":"11","author":[{"given":"Xupeng","family":"Zang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry Guangdong Provincial Key Laboratory of Agro\u2010Animal Genomics and Molecular Breeding College of Animal Science South China Agricultural University Guangzhou 510642 P. 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