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However, the specific nucleus in the amygdaloid complex and the neural circuitry governing seizures remain unknown. Here, it is discovered that activation of glutamatergic neurons in the posterior basolateral amygdala (pBLA) induces severe seizures and even mortality. The pBLA glutamatergic neurons project collateral connections to multiple brain regions, including the insular cortex (IC), bed nucleus of the stria terminalis (BNST), and central amygdala (CeA). Stimulation of pBLA\u2010targeted IC neurons triggers seizures, whereas ablation of IC neurons suppresses seizures induced by activating pBLA glutamatergic neurons. GABAergic neurons in the BNST and CeA establish feedback inhibition on pBLA glutamatergic neurons. Deleting GABAergic neurons in the BNST or CeA leads to sporadic seizures, highlighting their role in balancing pBLA activity. Furthermore, pBLA neurons receive glutamatergic inputs from the ventral hippocampal CA1 (vCA1). Ablation of pBLA glutamatergic neurons mitigates both acute and chronic seizures in the intrahippocampal kainic acid\u2010induced mouse model of TLE. Together, these findings identify the pBLA as a pivotal nucleus in the amygdaloid complex for regulating epileptic seizures in TLE.<\/jats:p>","DOI":"10.1002\/advs.202407525","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:45:21Z","timestamp":1730306721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy"],"prefix":"10.1002","volume":"11","author":[{"given":"Yan\u2010Hui","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology and Department of Psychiatry of the Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou 310058 China"},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain\u2010Machine Integration School of Brain Science and Brain Medicine Zhejiang 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