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To optimize implant design, understanding the interplay between biomaterials and host cells during the foreign body response (FBR) is crucial. Material properties are known to influence cellular behavior and can be used to manipulate cell responses, but predicting the right combination for the desired outcomes is challenging. This study explores\u00a0how combined physicochemical material properties impact early myofibroblast differentiation using the Biomaterial Advanced Cell Screening (BiomACS) technology, which assesses\u00a0hundreds of combinations of surface topography, stiffness, and wettability in a single experiment. Normal human dermal fibroblasts (NHDFs) are screened for cell density, area, and myofibroblast markers \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) and Collagen type I (COL1) after 24\u00a0h\u00a0and 7 days of culture, with or without transforming growth factor\u2010beta (TGF\u2010\u03b2). Results demonstrated that material properties influence fibroblast behavior after 7 days with TGF\u2010\u03b2 stimulation, with wettability emerging as the predominant factor, followed by stiffness. The study identified regions with increased cell adhesion while minimizing myofibroblast differentiation, offering the potential for implant surface optimization to prevent fibrosis. This research provides a powerful tool for cell\u2010material studies and\u00a0represents a critical step toward enhancing implant properties and reducing complications, ultimately improving patient outcomes.<\/jats:p>","DOI":"10.1002\/advs.202407531","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:05:43Z","timestamp":1733468743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Modulation of Biomaterial\u2010Associated Fibrosis by Means of Combined Physicochemical Material Properties"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-0072","authenticated-orcid":false,"given":"Lisa E.","family":"Tromp","sequence":"first","affiliation":[{"name":"Department of Biomaterials and Biomedical Technology University of Groningen, University Medical Center Groningen  FB\u201040, A. 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