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Antioxidants represented by \u03b1\u2010lipoic acid (ALA) have been demonstrated to scavenge ROS in the cochlea, while effective delivery of these agents in vivo remains a major challenge. Here, a novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable is presented ALA delivery and deafness prevention. As the composite microcarriers exhibit excellent bioadhesion and responsive hierarchical capabilities, this can result in a prolonged retention time in vivo and allow for precise ALA delivery under light stimulation, which significantly enhances the therapeutic efficacy of ALA. Based on these features, both in vitro and in vivo experiments are demonstrated that the composite microcarriers combined with near\u2010infrared light irradiation can effectively attenuate cisplatin\u2010induced ototoxicity. 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