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Single\u2010cell sequencing provides an in\u2010depth exploration at the single\u2010cell level and offers a deep understanding of tumor heterogeneity. Herein, single\u2010cell transcriptomics analysis is used to identify a unique malignant\u2010hepatoblast (HB)\u2010like cell subpopulation as the possible origin of poorly differentiated hepatoblastoma. These cells are associated with an unfavorable clinical prognosis in hepatoblastoma patients. The malignant\u2010HB\u2010like cell subpopulation generated insulin\u2010like growth factor 2 (IGF2) to sustain stem\u2010like features by promoting abnormal cholesterol accumulation via SREBF2. IGF2 also stimulated fibroblast 2 to secrete collagen 1, intensifying tumor malignancy via the collagen 1\/integrin \u03b11 signaling pathway. This suggests that targeting malignant HB\u2010like cells by inhibiting IGF2\u2010induced pathways can lead to promising treatments for hepatoblastoma. 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