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However, bladder cancer (BC) is usually classified as an immune \u201chot\u201d tumor, whereas prostate cancer (PCa) is deemed as an immune \u201ccold\u201d tumor according to the tumor microenvironment (TME) and clinical outcomes. To investigate the immune differences between BC and PCa, studies are compared focusing on immune regulation mediated by sex hormones and receptors to identify key genes and pathways responsible for the immune differences. From a developmental perspective, it is shown that PCa and BC activate genes and pathways similar to those in the developmental stage. During prostate development, the differential expression and function of the androgen receptor (AR) across cell types may contribute to its dual role in promoting and inhibiting immunity in different cells. Androgen deprivation therapy affects AR function in different cells within the TME, influencing immune cell infiltration and antitumor function. Additionally, estrogen\u03b1 and estrogen\u03b2 exert contrasting effects in PCa and BC, which may hold the potential for modifying the \u201ccold\u201d and \u201chot\u201d tumor phenotypes. Future research should target key genes and pathways involved in bladder development to clarify the immune regulatory similarities and differences between BC and PCa.<\/jats:p>","DOI":"10.1002\/advs.202407715","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T01:41:31Z","timestamp":1740534091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tracing the Evolution of Sex Hormones and Receptor\u2010Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-6758","authenticated-orcid":false,"given":"Dengxiong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of pathology Ningbo Clinical Pathology Diagnosis Center  Ningbo City Zhejiang Province 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Urology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouting","family":"Tuo","sequence":"additional","affiliation":[{"name":"Department of Urological Surgery Daping Hospital Army Medical Center of PLA Army Medical University  Chongqing 404100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koo Han","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Urology Kyung Hee University  Seoul 04510 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilinaer","family":"Wusiman","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology College of Veterinary Medicine Purdue University  West Lafayette IN 47907 USA"},{"name":"Purdue Institute for Cancer Research Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxia","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Public Research Platform Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Linhai 317000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Public Research Platform Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Linhai 317000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Three Gorges Hospital Chongqing University  Wanzhou Chongqing 404000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglin","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Affiliated Hospital of Southwest Medical University  Luzhou 646000 P. 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