{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:57:52Z","timestamp":1792515472279,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403056"],"award-info":[{"award-number":["82403056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273065"],"award-info":[{"award-number":["82273065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid synthesis. Mechanistically, RNF112 directly interacts with the MB II domain of MYC through its N\u2010terminal zinc finger motif, and its catalytic site C97 facilitates K48\u2010linked polyubiquitination of the K389 residue on the c\u2010Myc protein, accelerating its degradation. Additionally, this research validated the interaction of c\u2010Myc with the promoter of ATP citrate lyase (\n                    <jats:italic>ACLY<\/jats:italic>\n                    ), a central enzyme of lipid metabolism, promoting its transcriptional activity. The restoration of c\u2010Myc or ACLY expression attenuated the inhibitory effects of RNF112 on BLCA cell growth, migration, and lipid synthesis. In conclusion, this study confirmed that RNF112 suppressed the proliferation, migration, and lipid synthesis of BLCA cells by facilitating the ubiquitin\u2010mediated degradation of c\u2010Myc.\n                  <\/jats:p>","DOI":"10.1002\/advs.202408311","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:51:52Z","timestamp":1743803512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["RNF112 Facilitates Ubiquitin\u2010Mediated Degradation of c\u2010Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Kangping","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ultrasound Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Center for Evidence\u2010Based and Translational Medicine Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejinpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Sir Run Run Shaw Hospital of Zhejiang University  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-1265","authenticated-orcid":false,"given":"Kaiyu","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biological Repositories Human Genetic Resource Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-3628","authenticated-orcid":false,"given":"Lingao","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Biological Repositories Human Genetic Resource Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-1276","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Repositories Human Genetic Resource Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Euler Technology ZGC Life Sciences Park  Beijing 102206 China"},{"name":"Center for Quantitative Biology School of Life Sciences Peking University  Beijing 100091 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-9685","authenticated-orcid":false,"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biological Repositories Human Genetic Resource Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical Sciences  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-0024","authenticated-orcid":false,"given":"Xinghuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Medical Research Institute Frontier Science Center of Immunology and Metabolism Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-9020","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Zhongnan Hospital of Wuhan University  Wuhan 430071 China"},{"name":"Department of Biological Repositories Human Genetic Resource Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00468-9"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00744-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.028"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01607-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1226057"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02922-0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03521-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0479-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-20-98"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.166698"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.11.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05305-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2231"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.07.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38160-x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06446-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr155"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04867-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.07.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207549"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02921-9"},{"key":"e_1_2_9_15_3","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01890-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060310-170328"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.101807.093809"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.91"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-020-0458-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01291-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000019629"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2006.07.015"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.06.048"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00500-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00173-4"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014365"},{"key":"e_1_2_9_22_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1040965"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.019"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3403"},{"key":"e_1_2_9_24_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01553-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0301-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.10.004"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.005"},{"key":"e_1_2_9_26_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.12.010"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00845-0"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31249"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi2465"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02752-y"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202408311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202408311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202408311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:14:40Z","timestamp":1771323280000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202408311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":46,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/advs.202408311"],"URL":"https:\/\/doi.org\/10.1002\/advs.202408311","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"2024-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2408311"}}