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Dendritic cells (DCs) play a crucial role in combating the influenza A virus (IAV) by initiating adaptive immune responses. However, the impact of ID on DCs and their response to IAV infection remain unclear. This study showed that ID impairs the antigen\u2010presenting ability of DCs, thereby hindering their capacity to mediate T\u2010cell proliferation and clear viruses. The restrictive effects of ID on DCs begin in the bone marrow and specifically affect the monocyte DC progenitor (MDP) stage. A reduction in the number of MDPs and compromised immune potential lead to a decrease in the population and functionality of DCs in the subsequent common DC precursor (CDP) stage in the blood, spleen, and lungs. This study highlights the previously unrecognized impact of ID on DCs and provides valuable insights into immune cell responses and the application of iron supplementation in the fight against viral infections.<\/jats:p>","DOI":"10.1002\/advs.202408348","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T20:07:38Z","timestamp":1746043658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti\u2010Infection Capacity"],"prefix":"10.1002","volume":"12","author":[{"given":"Quanzhong","family":"Ren","sequence":"first","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing 100085 P. R. 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