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Recent advancements in adeno\u2010associated virus (AAV)\u2010mediated gene therapy offer promising new avenues for the treatment of inner ear diseases. Clinical trials of AAV\u2010mediated gene therapies show impressive preliminary results, although further research is needed to evaluate the safety and long\u2010term effects of these therapies. Preclinical AAV\u2010mediated gene therapy is notable for its high transduction efficiency and safety. In this article, the development of AAV\u2010mediated gene therapies is reviewed for inner ear diseases, categorizing these therapies by their strategies for treating hereditary hearing loss, including gene replacement and cluster regularly interspaced short palindromic repeat\u2010based methods. AAV\u2010mediated hair cell regeneration therapy is also reviewed for acquired hearing loss, as well as methods to prevent acquired hearing loss. 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