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Although immunotherapy has shown potential in achieving this goal, due to multiple immunosuppression and poor immunogenicity of apoptosis, a satisfactory anti\u2010recurrence effect still faces the challenge. Herein, an injectable hydrogel\u2010encapsulated autocatalytic copper peroxide (CP@Gel) therapeutic platform is designed and combine it with the clinical\u2010grade DNA methyltransferase inhibitor decitabine (DAC) to effectively inhibit TNBC growth and postoperative recurrence via pyroptosis, killing residual cancer cells that bypass apoptosis resistance while also improving immunogenicity and modulating immunosuppression to achieve an intense anti\u2010tumor immune response. Following injection of the CP@Gel, the sustained release of CP leads to the autocatalytic generation of reactive oxygen species, resulting in caspase\u20103 activation, and the pre\u2010administered DAC inhibits the methylation of\n                    <jats:italic>Gsdme<\/jats:italic>\n                    to elevate the GSDME protein levels, leading to intense pyroptosis and anti\u2010tumor immune responses. The in vivo results show a 67% elimination of local tumor recurrence via treatment with DAC+CP@Gel, suggesting the successful integration of sustained drug release with autocatalysis and epigenetic modification. The results thus suggest great potential for pyroptosis\u2010based and injectable hydrogel\u2010aided strategies for preventing the postoperative recurrence of TNBC.\n                  <\/jats:p>","DOI":"10.1002\/advs.202408415","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:40:10Z","timestamp":1730101210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhiping","family":"Rao","sequence":"first","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"},{"name":"Medical college Xi'an International University  Xi'an Shaanxi 710077 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University &amp; International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment  Xi'an Shaanxi 710126 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Man","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital of China Medical University Liaoning Cancer Hospital &amp; Institute  Shenyang Liaoning 110042 P. R. 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