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However, the inherent toxicity of metallic catalysts and numerous bacterial toxins during the therapeutic process still hinder its development. Herein, biomimetic metal\u2013organic (MOF@EV) nanosponges composed of ginger\u2010derived extracellular vesicles (EVs), and electrodynamic metal\u2013organic frameworks (MOFs) are developed for the eradication of bacterial infections and the absorption of toxins. The prolonged circulation time of MOF@EV in vivo facilitates their accumulation at infection sites. More interestingly, MOF@EV can behave as nanosponges and effectively prevent host cells from binding to bacterial toxins, thereby reducing damage to cells. Subsequently, the MOF@EV nanosponges are discovered to work as electro\u2010sensitizers, which is confirmed through both theoretical calculation and experimental verification. As a result, ROS is continuously produced under the electric field to achieve effective EDT\u2010mediated bacterial eradication. Meanwhile, the treatment process of MOF@EV in vivo is visualized in mice infected with luciferase\u2010expressing\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ), and excellent biofilm eradication capacity and detoxification efficiency are demonstrated in a subcutaneous abscess model. This work provides a promising strategy for the treatment of bacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202408442","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:40:07Z","timestamp":1729233607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biomimetic Electrodynamic Metal\u2010Organic Framework Nanosponges for Augmented Treatment of Biofilm Infections"],"prefix":"10.1002","volume":"11","author":[{"given":"Yanmin","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"},{"name":"College of Materials Science and Engineering Beijing University of Chemical Technology  Beijing 100029 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Materials Science and Engineering Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"},{"name":"College of Materials Science and Engineering Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"},{"name":"College of 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