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However, the effective systemic administration of platinum drugs and IDO\u20101 inhibitors is strictly limited by their distinct chemical construction, different pharmacokinetic profiles, and heterogeneous distributions. Herein, a novel supramolecular method with the capability to modulate tumor microenvironment is proposed aiming at potentiating the antitumor efficacy of chemoimmunotherapy. Profiting from the dynamic and reversible merits of noncovalent interactions, IDO\u20101 inhibitor (IDOi) and 1,2\u2010diaminocyclohexane\u2010platinum(II) (DACHPt) are tailor\u2010encapsulated into supramolecular nanoparticles (SNPs) with the aid of host\u2212guest recognition and metal coordination, respectively, effectively increasing the drug loading and improving their pharmacokinetics. In addition to the authorized chemotherapeutical effect, DACHPt performs a systemic antitumor immune response, which is further magnified by the IDOi\u2010reversed ITM to encourage T lymphocyte infiltration, guaranteeing long\u2010term antitumor immune responses to improve cancer prognosis.<\/jats:p>","DOI":"10.1002\/advs.202408518","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:05:20Z","timestamp":1738231520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Supramolecular Modulation of Tumor Microenvironment Through Host\u2212Guest Recognition and Metal Coordination to Potentiate Cancer Chemoimmunotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou 310014 P. R. 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