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However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self\u2010assembling nanoparticles, (2) self\u2010catalyzed synthesis of small\u2010molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self\u2010assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad\u2010spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant\u2010active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.<\/jats:p>","DOI":"10.1002\/advs.202408539","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:39:58Z","timestamp":1732595998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu\u2010an","family":"Li","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University  Yangzhou Jiangsu 225009 China"},{"name":"Jiangsu Co\u2010innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses  Yangzhou 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