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Recent multi\u2010omics studies highlight the prognostic value of disulfidptosis\u2010related gene (DRG) signatures in pan\u2010cancers; however, the molecular mechanisms underlying their biological functions and therapeutic relevance remain poorly defined. Herein, a DRG score model is constructed using LASSO Cox regression across 33 cancer types, and a nomogram incorporating the DRG score is developed for prognostic prediction. The tumor microenvironment, mutation profiles, and immunotherapy responses are analyzed. The DRG score serves as an independent prognostic factor across cancers, correlating with poor outcomes and malignant features. Glucose deprivation induces disulfidptosis in\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    cells (high\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    expression), especially in cancers with a high DRG score, such as ovarian cancer. Silencing\n                    <jats:italic>INF2<\/jats:italic>\n                    prevents disulfidptosis and decreases susceptibility to irofulven, which can be reversed by GLUT inhibitors.\n                    <jats:italic>SLC7A11<\/jats:italic>\n                    knockdown reduces disulfidptosis, restores ATP\/NADPH levels, and protects the cytoskeleton under glucose deprivation, whereas\n                    <jats:italic>INF2<\/jats:italic>\n                    knockdown impairs cell migration. Moreover, the DRG scores predict prognosis and therapeutic responses. The\n                    <jats:italic>SLC7A11\u2010INF2<\/jats:italic>\n                    axis regulates disulfidptosis, migration, and drug sensitivity, highlighting its potential as a marker of metabolic vulnerability in ovarian cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.202408556","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:43:58Z","timestamp":1753436638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Glucose Deprivation\u2010Induced Disulfidptosis via the\n                    <i>SLC7A11\u2010INF2<\/i>\n                    Axis: Pan\u2010Cancer Prognostic Exploration and Therapeutic Validation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1196-8952","authenticated-orcid":false,"given":"Zhenyu","family":"Song","sequence":"first","affiliation":[{"name":"Mini\u2010invasive Interventional Therapy Center Shanghai East Hospital Tongji University 200120 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuming","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Practice Zhongshan Hospital Fudan University Shanghai 200032 China"},{"name":"Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative Biology Fudan University Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The Affiliated Hospital of Youjiang Medical University for Nationalities Baise 533000 China"},{"name":"Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High\u2010Incidence Diseases of Baise Baise Guangxi 533000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cui","sequence":"additional","affiliation":[{"name":"Mini\u2010invasive Interventional Therapy Center Shanghai East Hospital Tongji University 200120 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongshan Hospital Fudan University Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhai","sequence":"additional","affiliation":[{"name":"Mini\u2010invasive Interventional Therapy Center Shanghai East Hospital Tongji University 200120 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9406-5106","authenticated-orcid":false,"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"GMU\u2010GIBH Joint School of Life Sciences The Guangdong\u2010Hong Kong\u2010Macao Joint Laboratory for Cell Fate Regulation and Diseases The Affiliated Traditional Chinese Medicine Hospital Guangzhou Medical University  Guangzhou Guangdong Province 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-6776","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongshan Hospital Fudan University Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-00834-8"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01091-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2024.06.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.2283"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2025.02.12"},{"key":"e_1_2_10_8_1","first-page":"105","volume":"10","author":"Joshi R. 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