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Due to the lack of available specifically treatment against MPV, developing an available vaccine is thus the most prospective and urgent strategy. Herein, a programmable macrophage vesicle based bionic self\u2010adjuvanting vaccine (AM@AEvs\u2010PB) is first developed for defending against monkeypox virus (MPV). Based on MPV\u2010related antigen\u2010stimulated macrophage\u2010derived vesicles, the nanovaccine is constructed by loading the mature virion (MV)\u2010related intracellular protein (A29L\/M1R) and simultaneously modifying with the enveloped virion (EV) antigen (B6R), enabling them to effectively promote antigen presentation and enhance adaptive immune through self\u2010adjuvant strategy. Owing to the synergistic properties of bionic vaccine coloaded MV and EV protein in defensing MPV, the activation ratio of antigen\u2010presenting cells is nearly four times than that of single antigen in the same dose, resulting in stronger immunity in host. Notably, intramuscular injection uptake of AM@AEvs\u2010PB demonstrated vigorous immune\u2010protective effects in the mouse challenge attempt, offering a promising strategy for pre\u2010clinical monkeypox vaccine development.<\/jats:p>","DOI":"10.1002\/advs.202408608","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:40:05Z","timestamp":1731055205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Programmable Macrophage Vesicle Based Bionic Self\u2010Adjuvanting Vaccine for Immunization against Monkeypox Virus"],"prefix":"10.1002","volume":"12","author":[{"given":"Weiqiang","family":"Lin","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Key Laboratory of Vascular Injury and Repair Research Ningxia Medical University  Yinchuan 750004 P. R. 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