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To address this, the Genetic Deafness Commons (GDC) is developed by consolidating extensive genetic and genomic data from 51 public databases and the Chinese Deafness Genetics Consortium. This repository comprises 5\u00a0983\u00a0613 variants across 201 HL genes, revealing the genetic landscape of HL and identifying six novel mutational hotspots within the DNA\u2010binding domains of transcription factors. Comparative phenotypic analyses highlighted considerable disparities between human and mouse models. Among the 201 human HL genes, 133 exhibit hearing abnormalities in mice; 35 have been tested in mice without exhibiting a hearing loss phenotype; and 33 lack auditory testing data. Moreover, gene expression analyses in the cochleae of mice, humans, and rhesus macaques demonstrated a notable correlation (R\n                    <jats:sup>2<\/jats:sup>\n                    0.718\u20130.752). Utilizing gene expression, function, pathway, and phenotype data, a SMOTE\u2010Random Forest model identified 18 candidate HL genes, including\n                    <jats:italic>TBX2<\/jats:italic>\n                    , newly confirmed as an HL gene. As a comprehensive and unified repository, the GDC advances audiology research and practice by improving data accessibility and usability, ultimately fostering deeper insights into hearing disorders.\n                  <\/jats:p>","DOI":"10.1002\/advs.202408891","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:24:11Z","timestamp":1742099051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["GDC: Integration of Multi\u2010Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss"],"prefix":"10.1002","volume":"12","author":[{"given":"Hui","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology West China Hospital of Sichuan University Chengdu 610000 China"},{"name":"Institute of Rare Diseases West China Hospital of Sichuan University Chengdu 610044 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