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Its pathogenesis involves an imbalance between connective tissue repair and degradation. CD34<jats:sup>+<\/jats:sup> cells comprise a heterogeneous population that exhibits stem cell and progenitor cell properties. However, the role of CD34<jats:sup>+<\/jats:sup> cells in abdominal aortic aneurysm (AAA) remains unclear. In this study, downregulated CD34 expression is observed in aneurysmal aortas from both patients and mouse models compared to that in non\u2010dilated aortas. Furthermore, by combining <jats:italic>Cd34<\/jats:italic>\u2010CreER<jats:sup>T2<\/jats:sup>;Rosa26\u2010tdTomato;(<jats:italic>Apoe<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) lineage tracing, bone marrow transplantation, and single\u2010cell sequencing, it is found that during AAA development, non\u2010bone marrow CD34<jats:sup>+<\/jats:sup> cells are activated to transdifferentiate into Periostin<jats:sup>+<\/jats:sup> myofibroblasts, thereby contributing to the formation of fibrotic collars. Dual recombinase\u2010based lineage tracing confirms the presence and involvement of CD34<jats:sup>+<\/jats:sup>\/Periostin<jats:sup>+<\/jats:sup> myofibroblasts in fibrotic collar formation during AAA development. Functionally, selective depletion of systemic or non\u2010bone marrow CD34<jats:sup>+<\/jats:sup> cells, as well as CD34<jats:sup>+<\/jats:sup>\/Periostin<jats:sup>+<\/jats:sup> myofibroblasts, by diphtheria toxin significantly exacerbates AAA progression and increases disease mortality. Mechanistically, it is identified that the PDGF\u2010PDGFRb\u2010PI3K axis is indispensable for Periostin<jats:sup>+<\/jats:sup> myofibroblast generation from non\u2010bone marrow CD34<jats:sup>+<\/jats:sup> cells in AAA, offering a new therapeutic target for patients with AAA at a high risk of rupture.<\/jats:p>","DOI":"10.1002\/advs.202408996","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T02:35:31Z","timestamp":1735353331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aneurysm Is Restricted by CD34<sup>+<\/sup> Cell\u2010Formed Fibrous Collars Through the PDGFRb\u2010PI3K Axis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3519-5994","authenticated-orcid":false,"given":"Hong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital Zhejiang University School of Medicine  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