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Although modified anti\u2010adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi\u2010functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester\u2010 and carbamate\u2010bonded CA (PEUU\u2010CA). PEUU\u2010CA is electrospun into bioactive patches that can uniquely present a sustained CA niche, referred to as BPSN. In the early stage of degradation, the breakage of the ester bond from BPSN is the dominant factor contributing to the early release of CA. In the later stage of BPSN degradation, the breakage of the ester and carbamate bonds contributes to the sustained release of CA. In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down\u2010regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage\u2010dominated biomaterial implantation and the issue of the short\u2010term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well\u2010known implant\u2010derived inflammatory responses.<\/jats:p>","DOI":"10.1002\/advs.202409128","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T14:50:26Z","timestamp":1733323826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion"],"prefix":"10.1002","volume":"12","author":[{"given":"Zaijin","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  600 Yishan Rd. 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