{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:38:25Z","timestamp":1790793505165,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment even more challenging. The optimal treatment strategy combines immune response modification to promote osteogenesis with effective bacterial infection removal that does not require long\u2010term antibiotic use. A one\u2010step plasma immersion ion implantation approach is used to create titanium alloy implants incorporating cobalt. According to experimental findings, cobalt\u2010containing titanium implants exhibit improved antibacterial activity by efficiently disrupting biofilm formations and reducing Methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    adherence by over 80%. Additionally, the implants exhibit superior anti\u2010inflammatory and osseointegration properties. RNA sequencing analysis reveals the potential mechanism of Co\n                    <jats:sup>2+<\/jats:sup>\n                    in regulating the polarization of macrophages toward the anti\u2010inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. Concurrently, these implants promote osteogenic differentiation while suppressing osteoclast activity, further supporting bone repair. Overall, without exogenous recombinant proteins or antibiotics, the implants effectively eradicate infections and expedite bone repair, offering a novel therapeutic strategy for complex skeletal diseases with clinical promise.\n                  <\/jats:p>","DOI":"10.1002\/advs.202409200","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:00:04Z","timestamp":1732593604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Multifunctional Cobalt\u2010Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage\u2010Mediated Immunomodulation"],"prefix":"10.1002","volume":"12","author":[{"given":"Nongyang","family":"Yan","sequence":"first","affiliation":[{"name":"Institute of Advanced Technology University of Science and Technology of China  No. 5089 Wangjiang West Road Hefei Anhui 230031 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