{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:53:49Z","timestamp":1790826829212,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1205704"],"award-info":[{"award-number":["2022YFA1205704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFB3801000"],"award-info":[{"award-number":["2021YFB3801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and the activation of protective mitochondrial autophagy severely restricts the therapeutic efficacy. Herein, an in situ transformable nanoparticle named\n                    <jats:bold>KCKT<\/jats:bold>\n                    is developed to promote lysosomal escape and directly damage mitochondria while blocking mitochondrial autophagy.\n                    <jats:bold>KCKT<\/jats:bold>\n                    exhibits acid responsiveness for precise self\u2010assembly into nanofibers within the lysosomes of cancer cells. The massive accumulation of nanofibers and excessive production of reactive oxygen species (ROS) under sonodynamic therapy synergistically induce lysosomal damage. This facilitates the escape of nanofibers from lysosomal sequestration, thereby enhancing drug delivery. Subsequently, the escaped nanofibers specifically aggregate around the mitochondria for long\u2010term retention and generate ROS under ultrasound irradiation to induce mitochondrial damage. Notably, due to lysosomal dysfunction, damaged mitochondria cannot be cleared by autophagy, further aggravating oxidative damage. These results reveal that\n                    <jats:bold>KCKT<\/jats:bold>\n                    effectively improves drug delivery and mitochondria\u2010targeted therapy efficiency by blocking protective autophagy. These findings hold significant potential for advancing the field of mitochondria\u2010targeted therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202409425","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T08:38:12Z","timestamp":1733733492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux"],"prefix":"10.1002","volume":"12","author":[{"given":"Yulin","family":"Lv","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Theranostics Harbin Medical University  Harbin 150001 China"},{"name":"Department of Urology Harbin Medical University Cancer Hospital  Harbin 150001 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University Cancer Hospital  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Theranostics Harbin Medical University  Harbin 150001 China"},{"name":"Department of Urology Harbin Medical University Cancer Hospital  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Theranostics Harbin Medical University  Harbin 150001 China"},{"name":"Department of Urology Harbin Medical University Cancer Hospital  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Molecular Probes and Targeted Theranostics Harbin Medical University  Harbin 150001 China"},{"name":"Key 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