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There are evidences to support the role of gut microbiota as a key player in reproductive development. Unfortunately, the relationship between reproductive disorders caused by aging and gut microbiota remains largely unknown. Here, it is shown for the first time that gut microorganism\n                    <jats:italic>Bacteroides fragilis<\/jats:italic>\n                    (BF) transplantation ameliorates ovarian aging by transporting extracellular vesicles (EVs) through the gut\u2010ovary axis. Mechanistically, miR\u20101246 is enriched in EVs derived from BF\u2010treated intestinal cells, and these miR\u20101246\u2010enriched EVs are transferred to ovaries, thereby effectively improving reproductive senescence by reducing oxidative stress in the ovaries. Specifically, miR\u20101246 reduces the ubiquitination of p62 and stabilizes the protein level of p62 by targeting E3 ligase SKP2. Then Keap1\u2010Nrf2 complex is dissociated and Keap1 is recruited to form the p62\u2010Keap1 complex. With the dissociation of Keap1\u2010Nrf2 complex, Nrf2 is released and activated, thus promoting the transcription of antioxidant enzymes and relieving reproductive senescence. Collectively, the data indicates that intestinal cell\u2010derived EVs serve as natural information carriers in the crosstalk between the gut and the ovary, and intestinal microorganism transplantation is a promising approach for the treatment of ovarian dysfunction diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202409740","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T15:06:51Z","timestamp":1736780811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut\u2010Ovary Axis"],"prefix":"10.1002","volume":"12","author":[{"given":"Yan","family":"Xiong","sequence":"first","affiliation":[{"name":"School of Life Sciences Chongqing University  Chongqing 401331 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