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Current treatments, including pharmacological and surgical interventions, are often associated with significant side effects and high recurrence rates. Consequently, there is an urgent need for innovative and safer therapeutic approaches. In this study, an injectable magnetic hydrogel nanosystem is developed designed for the dual\u2010purpose magnetothermal and anti\u2010inflammatory treatment of endometriosis. This hydrogel incorporates Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles alongside an anti\u2010inflammatory peptide. Upon magnetic activation, the Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles induce a localized hyperthermic response, raising the temperature of endometriotic lesions to 63.3\u00a0\u00b0C, effectively destroying endometriotic cells. Concurrently, the thermally responsive hydrogel facilitates the controlled release of the anti\u2010inflammatory peptide, thus modulating the inflammatory milieu. The biocompatibility and complete in vivo degradability of the hydrogel further enhance its therapeutic potential. The in vivo studies demonstrated that this injectable magnetic hydrogel system achieved a 90% reduction in the volume of endometriotic lesions and significantly decreased inflammatory markers, offering a promising non\u2010invasive treatment modality for endometriosis. By integrating precise lesion ablation with the modulation of the inflammatory microenvironment, this system represents a novel approach to the clinical management of endometriosis.<\/jats:p>","DOI":"10.1002\/advs.202409778","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:33:39Z","timestamp":1728290019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Injectable Magnetic Hydrogel Incorporated with Anti\u2010Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis"],"prefix":"10.1002","volume":"11","author":[{"given":"Huaichao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 250021 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