{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:09:14Z","timestamp":1791288554747,"version":"4.3.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1442100"],"award-info":[{"award-number":["20ZR1442100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole\u2010process repair hydrogel (APF\/C\/L@dECM) is designed. After rigorous testing, it is found that hydrogels formed by hydrophobic association and double cross\u2010linking of amide bonds can procedurally regulate wound healing in all phases to match the repair process. In rabbit models of urethral wound, APF\/C\/L@dECM hydrogel can achieve scarless reconstruction with significantly better results than other hydrogels. Noteworthily, multi\u2010stage mechanistic explorations reveal the expression profiles of inflammation, vascularization, and extracellular matrix secretion\u2010related genes in wound tissue at different times. In summary, this study develops an overall treatment for urethral injury through a whole\u2010process repair system that promotes healthy healing of urethral wounds and prevents the formation of scar tissue.<\/jats:p>","DOI":"10.1002\/advs.202409930","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:59:45Z","timestamp":1734494385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["An Integrated Whole\u2010Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4870-3382","authenticated-orcid":false,"given":"Wenzhuo","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University School of Medicine  No. 600 Yi\u2010Shan Road Shanghai 200233 P. 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