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Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here, a hybrid heterojunction system (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \/CuS\/Emo) is designed for curing bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. On the basis of the heterojunction formed by the two semiconductors, emodin is innovatively introduced to modify it. This integration not only accelerates the movement of charge carriers but also enhances polarization loss due to the numerous functional groups present on the surface. This further optimizes the microwave thermal and catalytic response. In addition, the unique anti\u2010inflammatory properties of emodin confer the ability of hybrid heterojunction to regulate the immune microenvironment. In vivo studies reveal that heterojunction modified by emodin programmed elimination of bacteria and regulation of the immune microenvironment. It offers a revolutionary approach to the treatment of bacterial osteomyelitis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202409979","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T02:59:32Z","timestamp":1732762772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Emodin Enhanced Microwave\u2010Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria\u2010Infected Osteomyelitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Tao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Research Center for Nano\u2010biomaterials &amp; Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Research Center for Nano\u2010biomaterials &amp; Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology  Taiyuan 030024 China"},{"name":"Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Research Center for Nano\u2010biomaterials &amp; Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Shi","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Pneumoconiosis Department of Pulmonary and Critical Care Medicine First Hospital of Shanxi Medical University  Taiyuan 030001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Research Center for Nano\u2010biomaterials &amp; Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology  Taiyuan 030024 China"},{"name":"Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and Engineering Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-9766","authenticated-orcid":false,"given":"Di","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Research Center for Nano\u2010biomaterials &amp; Regenerative Medicine College of Artificial Intelligence Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110428"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-019-0061-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210117"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26456-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100150"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102926"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08868"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.05.046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2019.02.016"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b01735"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.144688"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12081"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18268-0"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300203"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202307406"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1476"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20220161"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.12.023"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111596"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-187"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11448"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00606"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.01.027"},{"key":"e_1_2_8_16_3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312889"},{"key":"e_1_2_8_17_1","volume":"41","author":"Xing Y.\u2010Q.","year":"2022","journal-title":"Chin. 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