{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:16:50Z","timestamp":1788448610595,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360225"],"award-info":[{"award-number":["82360225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320. 6750.2023\u201024\u201013"],"award-info":[{"award-number":["320. 6750.2023\u201024\u201013"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post\u2010hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi\u2010omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH. Integrative multiomics analysis suggests that the over\u2010representation of ferroptosis, calcium, calcium ion binding, and cell adhesion signaling pathways is associated with PHH. Bioinformatic analysis indicates that chondroitin sulfate proteoglycan 4 (CSPG4) is discovered as a CSF biomarker and positively correlated with the ventricular size and the rate of periventricular leukomalacia. Next, it is further demonstrated that these signaling pathways are dysregulated in the choroid plexus (ChP) in PHH by using in vitro cellular experiments and rat models of PHH, whereas\n                    <jats:italic>CSPG4<\/jats:italic>\n                    silencing can suppress ferroptosis, cell adhesion function, and the intracellular flow of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . These findings broaden the understanding of the pathophysiological mechanisms of PHH and suggest that CSPG4 may be an effective therapeutic target for PHH.\n                  <\/jats:p>","DOI":"10.1002\/advs.202410056","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:43:55Z","timestamp":1734403435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of CSPG4 as a Biomarker and Therapeutic Target for Infantile Post\u2010Hemorrhagic Hydrocephalus via Multi\u2010Omics Analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-1908","authenticated-orcid":false,"given":"Juncao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neonatology Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8697-8564","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangzhou Women and Children's Medical Center Guangdong Provincial Clinical Research Center for Child Health  Guangzhou 510623 China"},{"name":"Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-5163","authenticated-orcid":false,"given":"Xiangwen","family":"Peng","sequence":"additional","affiliation":[{"name":"Changsha Hospital for Maternal and Child Healthcare  Changsha 410100 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