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A promising approach for improving thrombolysis efficiency is utilizing the permanent magnetically actuated locomotion of nanorobots. However, the thrombolytic drug transportation efficiency is challenged by in\u2010plane rotating locomotion and the insufficient drug penetration limits further improvement of thrombolysis. Inspired by ciliary movement for cargo transportation in human body, in this study, cilia\u2010mimic locomotion of magnetic colloidal collectives is realized under torque\u2010force vortex magnetic field (TFV\u2010MF) by a designed rotating permanent magnet assembly. This cilia\u2010mimic locomotion mode can generate more disturbances to the fluids to improve thrombolytic drug transportation and the increased height and area of colloidal collectives boosted the imaging capability. In addition, low\u2010intensity ultrasound is applied to enhance colloids infiltration by producing the fiber breakage and inducing erythrocyte deformation. In vitro thrombolytic experiments demonstrate that the thrombolysis efficiency increased by 16.2 times compared with that of pure tissue plasminogen activator (tPA)\u00a0treatments. Furthermore, in vivo rat models of femoral vein thrombosis confirmed that this approach can achieve blood flow recanalization more quickly. The proposed cilia\u2010mimic locomotion of magnetic colloidal collectives combined with low\u2010intensity ultrasound irradiation mode provides a new insight of therapeutic interventions for vascular thrombus by enhancing drug penetration.<\/jats:p>","DOI":"10.1002\/advs.202410351","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T02:46:33Z","timestamp":1735353993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cilia\u2010Mimic Locomotion of Magnetic Colloidal Collectives Enhanced by Low\u2010Intensity Ultrasound for Thrombolytic Drug Penetration"],"prefix":"10.1002","volume":"12","author":[{"given":"Jingjing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  No. 600, Yishan Road Shanghai 200233 P. R. 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