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Despite this, there is a lack of efficient TAM\u2010specific therapeutics capable of reducing SPP1 expression. Here, on a phenotypic screen is reported to identify small molecule SPP1 modulators in macrophages. Several hits and incorporated them into a TAM\u2010avid systemic nanoformulation are identified. It is shown that the lead compound (CANDI460) can down\u2010regulate SPP1 in vitro and in vivo and lead to tumor remissions in different murine models. These findings are important as they offer a promising avenue for developing novel therapeutic strategies targeting TAM.\n                  <\/jats:p>","DOI":"10.1002\/advs.202410360","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:40:51Z","timestamp":1733445651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Targeted SPP1 Inhibition of Tumor\u2010Associated Myeloid Cells Effectively Decreases Tumor Sizes"],"prefix":"10.1002","volume":"12","author":[{"given":"Benan","family":"Kartal","sequence":"first","affiliation":[{"name":"Center for Systems Biology Massachusetts General Hospital  185 Cambridge St, CPZN 5206 Boston MA 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Garris","sequence":"additional","affiliation":[{"name":"Center for Systems Biology Massachusetts General Hospital  185 Cambridge St, CPZN 5206 Boston 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