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Although some optical sensing materials are used in non\u2010invasive\u00a0devices for continuous glucose monitoring (CGM), surface or localized plasmon sensing material are seldom applied in CGM owing to modest sensitivity and bulk sensing apparatus. Herein, a metasurface (MGMSPR) biosensor based on the metasurface plasmon resonance chip modified with heterostructured Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    MXene\u2212Graphene oxide (MG) is reported, which potentially enables ultra\u2010sensitive glucose detection. The sensor consists of a dual\u2010channel microfluidic device integrated with silver mirror enhanced MGMSPR chips. Not only does it promote the entry of glucose oxidase (GOD) into the internal pores and enhance the stable fixation of GOD in the membrane, but also the integration of MG material provides a high specific surface area and unique electronic properties, thereby significantly enhancing the sensitivity of the MGMSPR sensor. The detection limit of MGMSPR biosensor is 106.8\u00a0\u00b5\n                    <jats:sc>M<\/jats:sc>\n                    . This pioneering approach opens new avenues for monitoring physiological parameters and process analytical technology on an optical platform, providing continuous health monitoring and production process control through optical sensors.\n                  <\/jats:p>","DOI":"10.1002\/advs.202410376","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:41:49Z","timestamp":1732171309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["MXene\u2212Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring"],"prefix":"10.1002","volume":"12","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology  1037 LuoYu Road Wuhan 430070 P. R. 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