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However, the mechanism underlying this association needs to be further elucidated. Circular RNAs (circRNAs) have emerged as an important topic in the field of epigenetics and are involved in various cancers. This study aimed to explore the molecular basis of PM\n                    <jats:sub>2.5<\/jats:sub>\n                    \u2010induced lung cancer from an epigenetic perspective and identify potential biomarkers. Initially, the construction of a chronic PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure model confirmed that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure promoted the malignant transformation of human bronchial epithelial (HBE) cells. Mechanistically, abnormally upregulated circDNA2 inhibited the tumor suppressor gene growth arrest and DNA damage 45 alpha (GADD45A) mRNA in an N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A)\u2010dependent manner, mediated by YTH N6\u2010Methyladenosine RNA Binding Protein F2 (YTHDF2) after PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure. Further analyses revealed that circDNA2 can specifically bind to the YTHDF2 LC domain to promote YTHDF2 protein liquid\u2013liquid phase separation (LLPS), providing sufficient evidence linking LLPS and particulate pollutant\u2010induced tumorigenesis. In conclusion, this study provides new insights into the role of circDNA2 in PM\n                    <jats:sub>2.5<\/jats:sub>\n                    \u2010induced lung cancer and confirms its clinical value as a potential prognostic biomarker for lung cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.202410532","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T15:05:04Z","timestamp":1737126304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CircDNA2\u2010Educated YTHDF2 Phase Separation Promotes PM\n                    <sub>2.5<\/sub>\n                    \u2010Induced Malignant Transformation Through the Blunting of GADD45A Expression"],"prefix":"10.1002","volume":"12","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety &amp; School of Public Health Kunming Medical University  Kunming 650500 P. 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