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Herein, a hydrophilic and lipophilic diblock polymer (HLDP) is designed and synthesized to prepare a series of HLDP nano\u2010protectants to explore the best HLDP nano\u2010protectant for anthracnose management. These results demonstrate that the HLDP\u2010CS nano\u2010protectant displays the best control effects on mango anthracnose via the direct pathogen inhibition and amplified plant immune responses. The HLDP can be spontaneously conjugated with CS into nanoscale spherical particles through hydrophobic interaction. The complexation of CS with HLDP remarkably improves the deposition and adhesion of CS droplets on mango leaves. The HLDP can interact with mycelium via electrostatic interaction to damage the cell wall\/membrane, which can act as an AI to directly suppress the spore germination and mycelial growth. Meanwhile, HLDP can be applied as an adjuvant for CS to amplify the plant immune responses via accelerating the biosynthesis of secondary metabolites and plant hormones. This work reports the multiple missions for nanomaterials in pathogen control, which proposes a novel strategy for designing nano\u2010protectant with dual\u2010synergistic mechanism.<\/jats:p>","DOI":"10.1002\/advs.202410585","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T14:49:13Z","timestamp":1731941353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Preparation of Multifunctional Nano\u2010Protectants for High\u2010Efficiency Green Control of Anthracnose"],"prefix":"10.1002","volume":"11","author":[{"given":"Jiaming","family":"Yin","sequence":"first","affiliation":[{"name":"Frontiers Science Center for Molecular Design Breeding Department of Plant Biosecurity College of Plant Protection China Agricultural University  Beijing 100193 China"},{"name":"Sanya Institute of China Agricultural University  Sanya 572025 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