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Although hydrogel\u2010based therapies have shown potential for mucosal repair, challenges remain due to inadequate targeting and low hydrogel density, leading to ongoing infiltration of harmful substances and delayed mucosal healing. In this study, an inflammation\u2010targeting\u2010triggered healing hydrogel (ITTH hydrogel) is developed, composed of polyvinyl alcohol\u2010alginate microgels (PALMs) and a cyclodextrin polymer crosslinker (CPC). This hydrogel specifically targets inflamed colonic sites and crosslinks in situ to form a dense network. The results demonstrate that the ITTH hydrogel adheres effectively to inflamed colonic tissue in both IBD mouse models and human samples. The dense crosslinked network acts like the mucosal barrier, preventing the penetration of detrimental substances such as bacteria and small molecules, thereby protecting the underlying mucosal tissue. Furthermore, the ITTH hydrogel significantly improved therapeutic outcomes in mice with dextran sulfate sodium (DSS)\u2010induced colitis. These findings suggest that the ITTH hydrogel is a promising candidate for in situ reconstruction of colonic mucosa and the treatment of IBD.<\/jats:p>","DOI":"10.1002\/advs.202411010","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:46:46Z","timestamp":1736988406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inflammation Targeting\u2010Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa"],"prefix":"10.1002","volume":"12","author":[{"given":"Gaoxian","family":"Chen","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Clinical and Translational Science Department of Pharmacology and Chemical Biology, &amp; Institute of Molecular Medicine School of Medicine Shanghai Jiao Tong University  Shanghai 200025 P. R. 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