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Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have been unable to address all the harmful factors and fail to achieve a complete clinical cure. Ferroptosis, a new form of programmed cell death characterized by lipid peroxidation, has become a pivotal contributor to dry eye oxidative stress\u2010driven pathology. Therefore, therapeutic targeting of ferroptosis may be an attractive option for dry eye management. Herein, a sialic acid\u2010targeting peptide\u2010modified liposome loaded with Cyclosporine A (CsA), a typical anti\u2010inflammatory drug, and Ferrostatin\u20101 (Fer\u20101), a selective ferroptosis inhibitor, is developed termed as CF@SNPs, for combing and sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid\u2010targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. The CF@SNPs treatment comprehensively alleviates DED symptoms, including improving corneal defects, augmenting goblet cell count, and restoring tear secretion. Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53\u2010SLC7A11\u2010GSH\u2010dependent ferroptosis and TNF\u2010\u03b1\u2010associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. These results underscore the promising potential of this superior nano\u2010formulation for DED pharmacotherapy.<\/jats:p>","DOI":"10.1002\/advs.202411172","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:05:21Z","timestamp":1732763121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Corneal Mucin\u2010Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yin","family":"Zhang","sequence":"first","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinglian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Luo","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeen","family":"Lv","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Han","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-7365","authenticated-orcid":false,"given":"Ke","family":"Yao","sequence":"additional","affiliation":[{"name":"Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aopr.2024.01.008"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c07817"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11514"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.01.026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100183"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.109955"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.12.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S126668"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.7904"},{"key":"e_1_2_8_11_1","volume":"9","author":"Paiva C. 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