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This study presents an innovative approach that harnesses controlled inflammation to guide neutrophil\u2010mediated drug delivery, effectively overcoming the limitations imposed by tumor heterogeneity. By inducing localized inflammation within tumors using lipopolysaccharide, it significantly amplify the recruitment of drug\u2010laden neutrophils to tumor sites, irrespective of specific tumor markers. This strategy not only enhances targeted drug delivery but also triggers the release of neutrophil extracellular traps, further potentiating the anti\u2010tumor effect. Crucially, this study demonstrates that potential systemic inflammatory responses can be effectively mitigated through neutrophil transfusion, ensuring the safety and clinical viability of this approach. In a murine breast cancer model, the method significantly impedes tumor growth compared to conventional treatments. This work offers a versatile strategy for precise drug delivery across diverse tumor types. The findings pave the way for more effective and broadly applicable cancer treatments, potentially addressing the long\u2010standing challenge of tumor heterogeneity.<\/jats:p>","DOI":"10.1002\/advs.202411307","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T11:54:07Z","timestamp":1736682847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlled Inflammation Drives Neutrophil\u2010Mediated Precision Drug Delivery in Heterogeneous Tumors"],"prefix":"10.1002","volume":"12","author":[{"given":"Yunfei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin 300211 P. R. 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