{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:04:19Z","timestamp":1792605859878,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Beh\u00e7et's uveitis (BU) is a severe ocular manifestation of Beh\u00e7et's disease, typically accompanied by abnormal neutrophil infiltration and hyperactivation. However, the underlying causes of excessive neutrophil extracellular traps (NETs) production and mechanisms by which NETs contribute to the pathogenesis of BU remain incompletely understood. Neutrophils from BU patients exhibit a higher propensity for NETs release compared to healthy controls. In the experimental autoimmune uveitis (EAU), neutrophils are observed to exert pro\u2010inflammatory effects through NETs. Clearing NETs can inhibit\u00a0T helper 17 (Th17) cell differentiation and significantly alleviate\u00a0EAU symptoms. In vivo and in vitro experiments demonstrate neutralizing IL\u201017A markedly reducing neutrophil infiltration and NETs formation in EAU. Single\u2010cell RNA sequencing confirms that CD44 plays a key role in mediating interactions between NETs and Th17 cells. Antagonizing CD44 inhibits the proportion of Th17 cells and NETs formation. Multiplex immunofluorescence and cell communication analyses further demonstrate interactions and colocalization between NETs and CD44\n                    <jats:sup>high<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in EAU. NETs induce Th17 differentiation via upregulating CD44, and in turn, Th17 cells secrete IL\u201017A to recruit neutrophils and promote NETs formation. Interrupting NETs\u2010CD44\u2010IL\u201017A feedback loop\u00a0may be a\u00a0potential\u00a0therapeutic target\u00a0for\u00a0BU.\n                  <\/jats:p>","DOI":"10.1002\/advs.202411524","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T18:26:18Z","timestamp":1741458378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["NETs\u2010CD44\u2010IL\u201017A Feedback Loop Drives Th17\u2010Mediated Inflammation in Beh\u00e7et's Uveitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0923-7248","authenticated-orcid":false,"given":"Yi","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 510060 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Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wen","sequence":"additional","affiliation":[{"name":"Bengbu Medical University  Bengbu Anhui 233030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Bu","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine Sun 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