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However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma\u2010like adhesive patches (HCSPs) are prepared through a multi\u2010step process. First, polyethylene glycol diacrylate is cast and cured within decellularized porcine cornea (DPC) templates. The DPCs are then enzymatically digested to obtain hydrogel skeletons, which are finally integrated with human corneal extracellular matrix and methacrylate gelatin. HCSPs replicate the ultrastructure, protein components, and optical properties of human corneas and exhibit improved anti\u2010swelling and anti\u2010degradation capabilities compared with conventional DPCs and recombinant human collagen patches. HCSPs can deliver methacrylate gelatin at the ocular surface temperature (37\u00a0\u00b0C) and achieve stable adhesion to the corneal stroma upon 405\u00a0nm light irradiation. Furthermore, HCSPs promote the survival and migration of corneal epithelial and stromal cells while preserving their phenotypes. In rabbit models of lamellar keratoplasty and microperforation repair, HCSPs accelerate epithelial healing, minimize suture\u2010associated complications, and maintain structural stability. These findings suggest that HCSPs are promising donor corneal substitutes for clinical applications.<\/jats:p>","DOI":"10.1002\/advs.202411540","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:05:39Z","timestamp":1737695139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation"],"prefix":"10.1002","volume":"12","author":[{"given":"Long","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Yang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University  Binzhou 264003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University (Shandong Eye Hospital)  Jinan 250021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-373X","authenticated-orcid":false,"given":"Weiyun","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Eye Institute of Shandong First Medical University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.17219\/pim\/127653"},{"key":"e_1_2_8_2_1","first-page":"214","volume":"79","author":"Whitcher J. 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