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Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice. Single\u2010cell RNA sequencing analysis demonstrated that the knockout of Syncrip disrupts the late\u2010stage neurogenesis, stalling transcriptional progression in RGCs. Mechanistically, Syncrip maintains the transcription of temporal process\u2010related transcription factors by recruiting stabilization complexes through phase separation, crucially regulating the Notch signaling pathway that determines the fate of RGCs. Furthermore, pathogenic human mutations in Syncrip weaken its phase\u2010separation capability, failing to form stable complexes normally. Thus, Syncrip acts as a mediator of posttranscriptional regulatory mechanisms, governing the fate progression of RGCs and the advancement of intrinsic temporal programs. This study establishes an intracellular mechanism for posttranscriptional regulation of progressive fate determination in cortical neurogenesis.<\/jats:p>","DOI":"10.1002\/advs.202411732","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:44:01Z","timestamp":1736239441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip"],"prefix":"10.1002","volume":"12","author":[{"given":"Jiarui","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry &amp; Molecular Biology Medical Primate Research Center Neuroscience Center Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College  Beijing 100005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry &amp; 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