{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:39:42Z","timestamp":1776465582848,"version":"3.51.2"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201005274"],"award-info":[{"award-number":["2022\u201005274"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201003219"],"award-info":[{"award-number":["2022\u201003219"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201001094"],"award-info":[{"award-number":["2021\u201001094"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009252","name":"Science for Life Laboratory","doi-asserted-by":"publisher","award":["REPLP1:005"],"award-info":[{"award-number":["REPLP1:005"]}],"id":[{"id":"10.13039\/501100009252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["874735 (VEO)"],"award-info":[{"award-number":["874735 (VEO)"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN211417Pj"],"award-info":[{"award-number":["CAN211417Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M20\u20100130"],"award-info":[{"award-number":["M20\u20100130"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","award":["M23\u20100189"],"award-info":[{"award-number":["M23\u20100189"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The high transmissibility and mutation ability of coronaviruses enable them to easily escape existing immune protection and also pose a challenge to existing antiviral drugs. Moreover, drugs only targeting viruses cannot always attenuate the \u201ccytokine storm\u201d. Herein, a synthetic heparan sulfate (HS) mimetic, HMSA\u201006 is reported, that exhibited antiviral activities against both the SARS\u2010CoV\u20102 prototype and Omicron strains by targeting viral entry and replication. Of particular note, HMSA\u201006 demonstrated more potent anti\u2010SARS\u2010CoV\u20102 effects than PG545 and Roneparstat. SARS\u2010CoV\u20102 is reported to hijack autophagy to facilitate its replication, therefore boosting autophagy can attenuate SARS\u2010CoV\u20102 infection. It is revealed that HMSA\u201006, but not a similar HS mimetic that failed to inhibit SARS\u2010CoV\u20102, can upregulate cellular autophagy flux. In addition, HMSA\u201006 was\u00a0found to robustly block the NLRP3\u2010mediated inflammatory reaction in SARS\u2010CoV\u20102 infected THP\u20101 derived macrophages as evidenced by a reduction in inflammasome formation and the subsequent decreased secretion of mature caspase\u20101 and IL\u20101\u03b2. The HMSA\u201006's inflammation inhibitory function is further confirmed using a LPS\/ATP\u2010stimulated THP\u20101 macrophage model. Altogether, this study has identified a promising HS mimetic to combat SARS\u2010CoV\u20102\u2010associated diseases by inhibiting viral infection and attenuating viral\u2010induced inflammatory reaction, providing insights into the development of novel anti\u2010coronavirus drugs in the future.<\/jats:p>","DOI":"10.1002\/advs.202411737","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:24:32Z","timestamp":1734341072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS\u2010CoV\u20102 Infection and Ameliorates Viral\u2010Induced Inflammation"],"prefix":"10.1002","volume":"12","author":[{"given":"Jiaxin","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology The Biomedical Center Uppsala University  Uppsala 75123 Sweden"},{"name":"Zoonosis Science Center Uppsala University  Uppsala 75123 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5ke","family":"Lundkvist","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology The Biomedical Center Uppsala University  Uppsala 75123 Sweden"},{"name":"Zoonosis Science Center Uppsala University  Uppsala 75123 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Guerrini","sequence":"additional","affiliation":[{"name":"Istituto Di Ricerche Chimiche e Biochimiche G. Ronzoni  Milan 20133 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Ferro","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  Brisbane QLD 4072 Australia"},{"name":"Australian Infectious Diseases Research Centre The University of Queensland  Brisbane QLD 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology The Biomedical Center Uppsala University  Uppsala 75123 Sweden"},{"name":"SciLifeLab Uppsala Uppsala University  Uppsala 75123 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-9278","authenticated-orcid":false,"given":"Jinlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology The Biomedical Center Uppsala University  Uppsala 75123 Sweden"},{"name":"Zoonosis Science Center Uppsala University  Uppsala 75123 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1177\/2632010X241228053"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.p1041"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030747"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.017"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh0117"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04532-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-02513-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010023\u201003119\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.020"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04411-y"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.045"},{"key":"e_1_2_9_9_1","first-page":"162","volume":"21","author":"Carabelli A. M.","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00884-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.819165"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118542"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4784"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05514-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00538"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade8778"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00713-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04802-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.06.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201707"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01413-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012222"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25015-6"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00916-7"},{"key":"e_1_2_9_20_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2022.01.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103803"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5400"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00057-22"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01688"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c01293"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.09.037"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24007-w"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104299"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad037"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.10.026"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01357-21"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202100681"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952916"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101346"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c20744"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201378"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c01223"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110049"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114227"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.12.010"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13122467"},{"key":"e_1_2_9_39_3","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28175"},{"key":"e_1_2_9_39_4","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084686"},{"key":"e_1_2_9_39_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109126"},{"key":"e_1_2_9_39_6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27965"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01831-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102387"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185261"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.575047"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2843"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abq1366"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-022-02961-8"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02791"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202411737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T14:07:22Z","timestamp":1765289242000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202411737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/advs.202411737"],"URL":"https:\/\/doi.org\/10.1002\/advs.202411737","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2411737"}}