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To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophisticated volatilomics technique, aimed at facilitating the rapid and convenient prediction of potential physical discomfort related to latrogenic botulism. The investigation identifies five volatile organic compounds (VOCs)\u2014acetone, styrene, ethanol, 2\u2010pentanone, and n\u2010butano\u2014as promising markers indicative of BoNT poisoning. Specifically, a handheld breath analyzer, featuring a yttrium stabilized zirconia (YSZ)\u2010based gas sensor array, alongside a wearable temperature sensor integrated with a bio\u2010compatible methacrylated gelatin (GelMA) sensing film, are developed to simultaneously monitor breath signal variations and body temperature fluctuations. Preliminary animal testing validates the effectiveness of the integrated approach, achieving an accuracy exceeding 91.2% in early detection of physical discomfort associated with BoNT poisoning. These promising findings represent a significant advancement towards the early identification of BoNT\u2010related issues, enabling timely intervention and improved management strategies.<\/jats:p>","DOI":"10.1002\/advs.202411738","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:30:44Z","timestamp":1734341444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaoyang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Micro\u2010Nano Science and Technology &amp; National Key Laboratory of Advanced Micro and Nano Manufacture Technology School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University  Shanghai 200240 P. 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