{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:23:29Z","timestamp":1786976609941,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3809902"],"award-info":[{"award-number":["2023YFB3809902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102689"],"award-info":[{"award-number":["32102689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275043"],"award-info":[{"award-number":["22275043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203184"],"award-info":[{"award-number":["52203184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC2060"],"award-info":[{"award-number":["2024NSFSC2060"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFH0057"],"award-info":[{"award-number":["2022YFH0057"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022YFH0062"],"award-info":[{"award-number":["2022YFH0062"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022ZYD0068"],"award-info":[{"award-number":["2022ZYD0068"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017526","name":"1000 Talents Sichuan Program","doi-asserted-by":"publisher","award":["2287"],"award-info":[{"award-number":["2287"]}],"id":[{"id":"10.13039\/100017526","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017526","name":"1000 Talents Sichuan Program","doi-asserted-by":"publisher","award":["1923"],"award-info":[{"award-number":["1923"]}],"id":[{"id":"10.13039\/100017526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rise of antibiotic resistance, coupled with a dwindling antibiotic pipeline, presents a significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic\u2010resistant pathogens. Nisin, a promising peptide antibiotic, exhibits potent bactericidal activity through a mechanism distinct from that of clinically used antibiotics. However, its cationic nature leads to hemolysis and cytotoxicity, which has limited its clinical application. Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use to deliver their genomes to host bacteria. These systems utilize bacteriophage receptor\u2010binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. Peptide antibiotics are loaded via dynamic covalent bonds, allowing for infection microenvironment\u2010responsive payload release. These nanodelivery systems demonstrate remarkable specificity against target pathogens and effectively localize to bacteria\u2010infected lungs in vivo. Notably, they significantly reduce the acute toxicity of nisin, rendering it suitable for intravenous administration. Additionally, these bacteriophage\u2010mimicking nanomedicines exhibit excellent therapeutic efficacy in a mouse model of MRSA\u2010induced pneumonia. The facile synthesis, potent antimicrobial performance, and favorable biocompatibility of these nanomedicines highlight their potential as alternative therapeutics for combating antibiotic\u2010resistant pathogens. This study underscores the effectiveness of bacteriophage mimicry as a strategy for transforming peptide antibiotics into viable therapeutics.<\/jats:p>","DOI":"10.1002\/advs.202411753","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T02:35:16Z","timestamp":1732588516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3976-860X","authenticated-orcid":false,"given":"Hongping","family":"Wan","sequence":"first","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Center for Infectious Diseases Control (CIDC) Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7866-5164","authenticated-orcid":false,"given":"Xinyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Center for Infectious Diseases Control (CIDC) Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3638-8786","authenticated-orcid":false,"given":"Shinong","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Center for Infectious Diseases Control (CIDC) Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1636-6867","authenticated-orcid":false,"given":"Jiarong","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Center for Infectious Diseases Control (CIDC) Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-0836","authenticated-orcid":false,"given":"Xu","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-7857","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9139-3139","authenticated-orcid":false,"given":"Yuanfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Translational Medicine Laboratory The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-644X","authenticated-orcid":false,"given":"Zhongqiong","family":"Yin","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-3360","authenticated-orcid":false,"given":"Xinghong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Sustainable Antimicrobials Department of Pharmacy, College of Veterinary Medicine Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Center for Infectious Diseases Control (CIDC) Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.75"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00993-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01054-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2030196"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00181-19"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.10.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201609079"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2013.763765"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05781-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.07.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30327-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03784-z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2020.1796576"},{"key":"e_1_2_9_15_1","volume":"67","author":"Zhao X.","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00027B"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.038"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14098"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.16.5.321-325.1928"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.11.009"},{"key":"e_1_2_9_22_1","first-page":"1","volume":"64","author":"Zhao X.","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129818"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301463200"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001424"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.04.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.08.013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.02.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.062"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49603-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.11.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.056"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121249"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.01.046"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.09.010"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28227-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406156"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.04.014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7915.2011.00259.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00366"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00682"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115049"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00385-x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103729"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c01992"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14098"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01360-9"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201205292"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00612-5"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.017"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00134-4"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.02.021"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902530"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16057"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0187-5"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2021.1874281"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.2.3.11780"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202411753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:16:59Z","timestamp":1759785419000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202411753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/advs.202411753"],"URL":"https:\/\/doi.org\/10.1002\/advs.202411753","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2411753"}}