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Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration\u2010induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30\u00a0s on followed by 30\u00a0s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)\u2010GABA signaling mediates short\u2010term intermittent vibration\u2010induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABA<jats:sub>A<\/jats:sub> receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. Finally, intermittent vibration not only enhances sleep but also reduces amyloid\u2010\u03b2 (A\u03b2) deposition and reverses memory defects in Alzheimer's disease models. In conclusion, the study defines a central neural circuit involved in mediating short\u2010term iVIS and the potential implications of vibration in treating sleep\u2010related brain disorders.<\/jats:p>","DOI":"10.1002\/advs.202411768","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T14:09:51Z","timestamp":1733839791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intermittent Vibration Induces Sleep via an Allatostatin A\u2010GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models"],"prefix":"10.1002","volume":"12","author":[{"given":"Yang","family":"Mou","sequence":"first","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"He","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, and Institutes of Brain Science Fudan University  Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence Ministry of Education Behavioural and Cognitive Neuroscience Center Institute of Science and Technology for Brain\u2010Inspired Intelligence MOE Frontiers Center for Brain Science Fudan University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-5471","authenticated-orcid":false,"given":"Yong","family":"Ping","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.032"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.10.082"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80877-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.91355"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108462"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0400-21.2021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.12.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.4.528"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.6.533"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.05.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19880-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.12.028"},{"key":"e_1_2_9_13_1","first-page":"1146","volume":"13","author":"Sluijs R. 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