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Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA\u2010PDMS)\u2010coated cochlear electrode is presented for CI and hearing protection. The porous MA\u2010PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:sub>x<\/jats:sub>\n                    MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug\u2010loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.\n                  <\/jats:p>","DOI":"10.1002\/advs.202412158","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T16:14:09Z","timestamp":1747066449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-0798","authenticated-orcid":false,"given":"Lei","family":"Ren","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High Tech Key Laboratory for 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