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Herein, an engineered microneedle (MN) patch is reported to mediate the efficient delivery of black phosphorus nanosheets (BP NSs) and copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization and methicillin\u2010resistant staphylococcus aureus (MRSA)\u2010infected wound healing. Results demonstrate that the system can eliminate biofilm, reduce cytotoxicity, promote angiogenesis and tissue regeneration by the multiple advantages of chemodynamic therapy (CDT), enhanced photodynamic therapy (PDT), and improved degradation process from BP NSs to phosphate for promoting cell proliferation. Notably, the balance between excellent photodynamic stability and rapid degradability of BP NSs is maintained, and the improved degradation mechanism of BP NSs is vividly elucidated by density functional theory (DFT)\u2010based molecular dynamics (MD) calculations. Furthermore, the transcriptional changes of treated MRSA\u2010infected skin are studied using RNA\u2010seq technology to reveal the potential therapeutic mechanism. As envisaged, the proposed MN patch provides a safe, easy, also highly effective approach to achieve the temporal regulation of sterilization and tissue regeneration for bacterial biofilm\u2010infected wounds.<\/jats:p>","DOI":"10.1002\/advs.202412226","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T14:31:48Z","timestamp":1736778708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management"],"prefix":"10.1002","volume":"12","author":[{"given":"Shiyang","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine School of Chemical Science and Engineering Shanghai Tenth People's Hospital of Tongji University Tongji University  Shanghai 200092 P. R. 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