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Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue\u2010like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode\u2010tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue\u2010like modulus (less than 0.8\u00a0MPa at 37\u00a0\u00b0C) after implantation. The central core is altered from the tri\u2010arm crosslinker to the star\u2010branched monomer to kill two birds (close the translation temperature to 37\u00a0\u00b0C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1\u00a0\u00b1\u00a046.9\u00a0\u03a9 at 1\u00a0kHz) and increased charge storage capacity (111.2\u00a0\u00b1\u00a05.8\u00a0mC\u00a0cm<jats:sup>\u22122<\/jats:sup>) are achieved by an in situ electrografted conductive polymer on the strain\u2010insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long\u2010term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.<\/jats:p>","DOI":"10.1002\/advs.202412361","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T04:26:52Z","timestamp":1733459212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Body\u2010Temperature\u2010Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-9948","authenticated-orcid":false,"given":"Xueyang","family":"Ren","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Informatics Nanjing Medical University  Nanjing 211166 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