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The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery. This study describes a self\u2010healing hydrogel H@EFCP, which is designed to alleviate inflammatory pain and post\u2010burn depression in burn injuries. This hydrogel is synthesized through the cross\u2010linking of carboxymethyl chitosan with borate ester chelates formed from epigallocatechin gallate and 4\u2010formylphenylboronic acid. The incorporated Prussian blue nanoparticles increase the ability of H@EFCP to regulate the inflammatory process. H@EFCP is effective in the treatment of skin burns by reducing oxidative stress and improving the microenvironment of peripheral inflammation in mice. This modulation consists of a reduction of central nervous system inflammation and the risk of post\u2010burn depression. Behavioral assays indicate that the hydrogel significantly reduces feelings of despair and anxiety after burns. Consequently, H@EFCP provides a dual\u2010effect solution for the care and recovery of burn patients, including both burn repair and the associated psychological effects.<\/jats:p>","DOI":"10.1002\/advs.202413032","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T12:03:28Z","timestamp":1735128208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nanoenzymes\u2010Integrated and Microenvironment Self\u2010Adaptive Hydrogel for the Healing of Burn Injury and Post\u2010Burn Depression"],"prefix":"10.1002","volume":"12","author":[{"given":"Weitao","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy Nankai University  Haihe Education Park, 38 Tongyan Road Tianjin 300353 P. R. 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